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What is codeine? How
does it work (mechanism of action)?
Codeine is a narcotic pain-reliever and cough suppressant similar to morphine and hydrocodone.
Moreover, a small amount of codeine is converted to morphine in the body. The precise
mechanism of action of codeine is not known; however, like morphine, codeine
binds to receptors in the brain (opioid receptors) that are important for
transmitting the sensation of pain throughout the body and brain. Codeine
increases tolerance to pain, decreasing discomfort, but the pain still is
apparent to the patient. In addition to reducing pain.
Codeine is an opioid pain reliever used to treat mild to
moderately severe pain. It is also used, usually in combination with other
medications, to reduce coughing. Codeine
is available as a single-ingredient product, or in combination with
acetaminophen or aspirin, and in some cough and cold medications.
What are the side
effects of codeine?
The most frequent side
effects of codeine include:
·
Lightheadedness
·
Dizziness
·
Nausea
·
Vomiting
·
Sedation
·
Allergic
reactions
·
Constipation
·
Abdominal
pain
·
Rash
·
Itching
Serious side effects of
codeine include:
·
Life-threatening respiratory depression
·
Severe
low blood pressure
·
Adrenal
insufficiency
·
Accidental
ingestion of codeine can result in fatal overdose
Proper Use
Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer
time than your doctor ordered.
Dosing
The amount of medicine that you take depends on the strength
of the medicine. Also, the number of doses you take each day, the time allowed
between doses, and the length of time you take the medicine depend on the
medical problem for which you are using the medicine.
·
For
oral dosage form (tablets):
·
For
mild to moderate pain:
Adults—At first, 15 to 60 milligrams (mg)every 4 hours as needed. Your doctor may increase your dose as needed. However,
the dose is usually not more than 360 mg per day.
Children 12 to 18 years of age—Use and dose
must be determined by your doctor.
Children younger than 12 years of age—Should not be used in
these patients.
Precautions
This medicine may be habit-forming. If you feel that the
medicine is not working as well, do not use more than your prescribed dose.
Call your doctor for instructions.
Dizziness, lightheadedness, or fainting may occur when you
get up suddenly from a lying or sitting position. Getting up slowly may help.
Also, lying down for a while may relieve dizziness or lightheadedness. If this
problem continues or gets worse, check with your doctor right away.
This medicine may make you dizzy, drowsy, confused, or disoriented. Do not drive or do anything else that could be dangerous until you
know how this medicine affects you.
Using narcotics for a long time can cause severe
constipation. To prevent this, your doctor may direct you to take laxatives,
drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to
follow the directions carefully, because continuing constipation can lead to more serious problems.


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