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What is codeine? How does it work (mechanism of action)?

 Codeine is a narcotic pain-reliever and cough suppressant similar to morphine and hydrocodone. Moreover, a small amount of codeine is converted to morphine in the body. The precise mechanism of action of codeine is not known; however, like morphine, codeine binds to receptors in the brain (opioid receptors) that are important for transmitting the sensation of pain throughout the body and brain. Codeine increases tolerance to pain, decreasing discomfort, but the pain still is apparent to the patient. In addition to reducing pain.



Codeine is an opioid pain reliever used to treat mild to moderately severe pain. It is also used, usually in combination with other medications, to reduce coughing.  Codeine is available as a single-ingredient product, or in combination with acetaminophen or aspirin, and in some cough and cold medications.

What are the side effects of codeine?

The most frequent side effects of codeine include:

·        Lightheadedness

·        Dizziness

·        Nausea

·        Vomiting

·        Shortness of breath

·        Sedation

·        Allergic reactions

·        Constipation

·        Abdominal pain

·        Rash

·        Itching

 

Serious side effects of codeine include:

 

·        Life-threatening respiratory depression

·        Severe low blood pressure

·        Adrenal insufficiency

·        Accidental ingestion of codeine can result in fatal overdose

 


Proper Use

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Dosing

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

·        For oral dosage form (tablets):

·        For mild to moderate pain:

Adults—At first, 15 to 60 milligrams (mg)every 4 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 360 mg per day.

Children 12 to 18 years of age—Use and dose must be determined by your doctor.

Children younger than 12 years of age—Should not be used in these patients.

Precautions

This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help. Also, lying down for a while may relieve dizziness or lightheadedness. If this problem continues or gets worse, check with your doctor right away.

This medicine may make you dizzy, drowsy, confused, or disoriented. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.

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