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What is Tramadol? Tramadol is a strong painkiller. It's used to treat moderate to severe pain, for example after an operation or a serious injury. It's also used to treat long-standing pain when weaker painkillers no longer work. Tramadol is available only on prescription. The extended-release formulations of tramadol are typically given to people who need around-the-clock pain relief for an extended period of time. They’re not to be used for brief bouts of pain. Tramadol is in a class of drugs called opiate (narcotic) analgesics. It works by altering the way your brain and nervous system respond to pain. The U.S. Food and Drug Administration (FDA) approved this medicine in 1995. What is the most important information I should know about Tramadol (Ultram)? You should not take tramadol if you are allergic to it, or if you have: severe asthma or breathing problems; 1. a stomach or bowel obstruction (including paralytic ileus); ...